One of the defining and debilitating marks of depression is the feeling of loneliness and isolation. For many, living with depression feels like a giant dark veil has been dropped on the world — you can see others, but they can’t see you.

Around one-third of people with depression suffer from severe depression that resists clinical practice treatment options. If you cope with a mood disorder like depression and feel like your depressive episodes have turned into a single, long-term never-ending episode, you may have treatment-resistant depression.

Men are only half as likely to be diagnosed with depression, but almost four times more likely to die from suicide than women.